Instructor: Dr. Paul Wanda
Classroom: SL1105
Office: SL 3318
SL - (618)650-2336
Email: pwanda@siue.edu
URL (My Web Page): http://www.siue.edu/~pwanda/
Office Hours : . Office Hours will be : Monday & Wednesday or Friday 1:00pm - 2:00pm or by appointment- please email me if you need a quick response.
Any CHANGES to our schedule/topics will be posted in the 'Weekly
Objectives' link (click on link )
Graduate Teaching Assistants: Jason Allen and Mike Gitcho
Text: Essentials of Cell Biology, by Alberts, et al
Course/Learning Objectives:
To understand the problems in cell biology
To understand the molecular basis of cell biology - how things work
To improve quantitative skills through the use of research methods and analysis of figures & data
Course Description:
This course deals primarily with 'eukaryotic cell biology at the molecular level' such as protein-protein, protein-nucleic acid, and protein-lipid interactions , the synthesis and expression of the genome and communication between cells. This is cell biology at the molecular level.
Although many of you are familar with some experimental techniques, there are some applications that are unique to this course and perhaps not in your technical toolkit, so we will deal with learning objectives that address competence in the use of biotechnology, instrumentation, and research methods in cell & molecular biology. Additional learning objectives will introduce challenges to your analytical and intuitive skills by analyzing figures and data in the laboratory and in small group interactions. Lastly, a learning objective addressing introduction to quantitative skills will be covered in several laboratory topics . A brief outline for the course is listed below. Syllabus details will be posted on our Web site usually on a weekly basis and you should consult the 'calendar' provided with the daily topic listing.. Sometimes we may have to skip or spend extra time on a topic. We will have a couple of exam 'review' days instead of lecture - this way, we have the room and time provided (logistics are tricky otherwise) . Reading assignments are highly recommended ; this is such a well written book. Reading will be detailed in the 'Weekly Objectives'. If there is outside reading it will be provided by either posting material on reserve at the library , or in our Biol . 319 showcase (outside of lab 3215) or as class handouts. Although we will primarily cover animal cell biology, plant, bacterial,and viral systems will be explored as important examples. We occasionally will work out problems at the end of the chapter or from other sources. You are at the stage of your Biological Development where problem-solving is important , whether it be in lab or lecture. We will also see 2 or 3 films in place of a lecture. Lectures will focus on mechanisms - how things work
I strongly recommend ongoing construction of a vocabulary deck/ list if you are unfamilar with terms used in lecture.
It is assumed that the fundamentals of animal and plant biology as well as genetics are a part of your background ( the first three core courses in our biology curriculum). Organic chemistry (Chem. 241A or equivalent) is also required.
Course Policies:
School closing(s): Exams that are postponed due to the University closure (bad weather) or a science building evacuation will be rescheduled for the next class meeting.
Assigned number: Each student will receive an assigned number to use for identification for any posted grades on the Web Site (check the Biol. 319 showcase (outside SL3215 ) site for any lab grades).
Please refrain from munching on noisy snacks during lecture.
Also, please do not bring children (ps - I love kids) to class. Emergency situations will happen and we can
deal with these on a case by case basis if discussed prior to lecture.
Incompletes: Incomplete grades will be given only to students unable to complete the required course work because of a verifiable crisis and at the discretion of the instructor. The College of Arts and Sciences has an approved contract form dealing with incompletes; see me for information if this applies to your situation. Incompletes will NOT be given for bad grades.
Exam issuance and make-ups: No test will be handed out to a student after the first person hands in a test. No extra time will be given to any student coming late to the test. Please remove caps or hats during the exam and sit 2 seats apart. Assigned numbers 1-60 will take the exams in our LECTURE HALL, but assigned numbers 61 - 80 will take exams in our CELL LAB. Please note this!!
Each student may makeup one exam if you take the makeup exam within one lecture of the scheduled exam date by calling my office (618-650-2336) or email (pwanda@siue.edu) BEFORE the scheduled exam. If you had an emergency that prevents this, please discuss this with Dr. Wanda as soon as possible. Make-up exams will usually have different questions and be primarily in an essay format. Students traditionally do 'better' on the regular in-class exam. Use the make-up if you have a genuine emergency or illness.There will be no make -up exam for the optional final exam.
Exam seating: The instructor or TA reserves the right to relocate students during an exam or quiz .
Attendance: Class attendance in lecture is required. Attendance will be taken during the first week of class. Students who do not attend the first week of class will be removed from the class list. Since the exams cover a big portion of lecture material and class handouts, the easiest way to earn a good grade is to come to class and to have a good set of lecture notes. The textbook will serve both as a reference source for the material covered in lecture and as a direct source of exam questions. The instructor assumes that all students are attending class regularly , doing the assigned reading , using the Web site and that they are therefore fully informed of any announcements made in class or posted on the Web site).Your continued enrollment in this course indicates that you have read and understood this syllabus by signing the last page of the syllabus (which has your assigned number)..
Withdrawals: If you stop attending class and taking tests without discussing it with Dr. Wanda, you will get a UW. The final day to withdraw from class without the permission of your advisor and the instructor is October 26, 2001. Students who withdraw after that time may receive a WP or WE based on work to date (the grade percentage includes any missed test BEFORE the withdrawal) and must have the permission of the instructor.
Lecture Topics
Week 1 - Syllabus , Chemical bonds, Bioatoms & Biomolecules ; Read Chapter 2 for Week 1 & 2
Week 2 - Proteins - to - Prions (proteins gone bad) . Read pgs. 84-88 and 134-154 ; Friday - Film on Prions and Mad-Cow Disease
Week 3 - Monday - NO CLASS (Labor Day) Use of Radioisotopes and Fluorescence in Cell& Molecular Biology - see pgs 4F, 130, 317F, and 318.
Week 4 - DNA structure. replication, special eucaryotic DNA properties. Read Chapter 6.
Week 5 - RNA - mRNA, tRNA, and rRNA; Read Chapter 7. Friday will be exam #1 -Review Day
Week 6 - Exam #1 - on Monday 9/24/01. Translation ; Read pgs. 224-234.
Weeks 7-10- RNA processing and splicing details , Read 218-221 ; Lipids , Membrane proteins, and Membrane structure Read Chapter 12; On Friday (10/26/01) we will have Exam #2 Review Day on material covered since exam #1). We will study how proteins are made in the rough endoplasmic reticulu and the Phosphoinisitol signal pathway, Membrane fusion, and Transport mechanisms. Read Chapter 14..
Weeks 11-12- On Monday (10/29/01) we will have Exam #2 ; Cell Communication/miscommunication; Read pgs. 481-489 and 493-497 in Chapter 15. Also Lysosomes, Peroxisomes, and Neurotransmitters , Ion channels, and Membrane potentials - Read Chapter 14 and pgs. 386-403.
Weeks 13-15 - Cell cycle (read 572-581); Oncogenes (Read pgs. 302-03 and 588-89); Genetic Basis of Cancer Film; Apoptosis (programmed cell death); On Wednesday, 12/5/01, we will have Exam#3; On Friday, 12/07/01, we will have a Review Day for those electing to take the Optional Comphrehensive Final Exam.
Finals week - Comprehensive Optional Final Exam ( 120 points ; format similar to other class exams) ; You can elect to take this exam during the regularly scheduled final exam time ( 12/11/01 at 10-11:40 am) only if you wish to erase your lowest exam score; it will not count as your lowest exam score ; there is NO make-up for the final exam. Note : this exam will substitute for your lowest exam score (one exam only) .
* Please note that additional details on topics and reading will be available in the 'Weekly Objectives' link posted on the Web site.
Important Dates:
Exam #1 (120 points) - 9/24/01
Exam #2 (120 points) - 10/29/01
Exam #3 ( 120 points) - 12/06/01
Lab portion (160 points)
Total possible points = 520 (360 (lecture) + 160(lab))
Exam Format and Final Grades:
Exam questions will include short essay, short
answer , multiple choice and problem solving formats . Letter grades will be based as follows: 90 - 100%, A; 80- 89%
,B; 70- 79% ,C; 60- 69%, D; less than 60%, E.
Exams will generally be graded within two days, however recording grades and preparing the 'return' package is time-consuming so all this may take one week (however the scores will be posted on our Web site asap, if our SIUE system allows it). You can easily determine your grade status at any time by calculating your lecture percentage from this site and your lab grade percentage from listed scores.
Your signiture on the last enclosed page will signify your agreement to the policies stated in this syllabus - this page MUST be returned by Friday of week #1 if you intend to remain enrolled in this course. Be sure to record the assigned number in your notebook or elsewhere. THANK YOU!
| Assigned #* | exam #1 scores are curved (9/27/01) - Average =70%Exam #2 scores are curved (11/02/01) - Exam #3 scores are curved (12/06/01); Optional Final Exam scores are curved 912/13/01) |
| 1 | 91, +3, 81, +4, 95 |
| 2 | 74.5, +4, 82, +5, +5, 72, FE=62 |
| 3 | 86, +2, 74, 56, FE=70 |
| 4 | 70, +3, 72.5, 48 |
| 5 | *72, +4, +5, 86, +4, +5, 79 |
| 6 | 88, +4, 93, +5, +5, 68, FE=70 |
| 7 | 109, +4, +5, +4, 113, +5, +5, 107 |
| 8 | 104, +3, +5, +4, 101, +5, +5, 112 |
| 9 | 51, 68, 53, FE=81 |
| 10 | 96, 76, 82 |
| 11 | 86, +2, 74.5, 76, FE=63 |
| 12 | 130, +2, +5, +2, 107, +5, +5, 112 |
| 13 | 85, 63, +5, 69.5, FE=72 |
| 14 | 91, +3, +5, +4, 73.5, +5, +5, 76, FE=65.5 |
| 15 | 71, +1, +5, +2, 78, +5, 45, FE=80 |
| 16 | 86, +1, 69, 86 |
| 17 | 109, 103, +5, 92 |
| 18 | 45, +3.5, +2, 0 |
| 19 | 80, 59, +5, +5, 97, FE=74 |
| 20 | 94, +1, +5, 80, +5, 68.5 |
| 21 | 75, +1, +2, 79, 43, FE=76 |
| 22 | 98, +4, +5, 114, +5, +5, 93 |
| 23 | 112, +1, +2, 99, +5, 94, FE=96 |
| 24 | 55, +2, +5, +2, 91, +5, 78, FE=102 |
| 25 | 108, +1, +5, 101, +5, 95, FE=103 |
| 26 | 79, 101, +5, 92, FE=112 |
| 27 | 111.5, +3, +5, +4, 101, +5, +5, 98.5 |
| 28 | 73, +3, +5, 93.5, 83, FE=80 |
| 29 | 86, +2.5, +4, +5, +4, 113.5, +5, +5, 95 |
| 30 | 69, +3, 115, +3, +5, 93 |
| 31 | 90, +1, 79, +5, +5, 76 |
| 32 | 101, 111, 105 |
| 33 | 85.5, +3.5, 81, +5, +5, 92 |
| 34 | 107, +5, +3, +5, +5, 113, +5, 104 |
| 35 | 71, +2, +4, 66, 63, FE=90 |
| 36 | 63, +2, +4, 61, +5, +5, 102, FE=90 |
| 37 | 91, +3.5, +4, 90, +3, 84, FE=78 |
| 38 | 97, +4, *95, +5, 81, FE=64 |
| 39 | 55, +2, +5, +3, 64, +5, 45, FE=67 |
| 40 | 123, +5, +5, +4, 120, +5, +5, 120 |
| 41 | 38, +2, +4, +3, 71, +4, 69.5, FE=62 |
| 42 | 73, +1, +5, 85.5, +5, +5, 57 |
| 43 | 55.5, +2, 44, 60.5, FE=76 |
| 44 | 51, +2, +5, +2, 64.5, +5, 56, FE=72 |
| 45 | 93, +3, +5, +2, 113.5, +5, +5, 114 |
| 46 | 104.5, 102, 108.5 |
| 47 | 58, +1, +5, +4, 99, +5, +5, 83, FE=107 |
| 48 | |
| 49 | 37.5, +3, +3, 47, +5, +5, 66, FE=51 |
| 50 | 99, +2.5, +5, 71.5, 79.5, FE=90 |
| 51 | 57, +1, 79, 80, FE=98 |
| 52 | 81.5, +3.5, +5, +4, 71.5, +4.5, +5, 94, FE=78 |
| 53 | 45, +3, +5, 0 |
| 54 | 81.5, +5, +3, 81, +5, 65, FE=67 |
| 55 | 80, +3, +3, 61, +5, +5, 78, FE=77 |
| 56 | *26, +2, +5, 100, +5, +5, 75, FE=69 |
| 57 | 88, +1, +5, 85, +5, +5, 63, FE=99 (ok) |
| 58 | 113, +2.5, +3, +3, 101, +5, 86, FE=107 |
| 59 | 85, +2.5, 64, +5, 92, FE=62 |
| 60 | 107, +1, 103, 107.5 |
| 61 | 58, +1, 89, +5, +4, 70, FE= 85 |
| 62 | 71, +2, +5, 77, +5, +5, 80.5 |
| 63 | 86, +1, 73.5, 81, FE=102 |
| 64 | 117.5, +2, +5, 114.5, 120 |
| 65 | 87, 83, +4, +5, 106, FE-76 |
| 66 | 96, +2, +5 , +4, 99,+5, +5, 67, FE=81 |
| 67 | 90, 86, 65, FE=88.5 |
| 68 | 52, +2, +5, +3, 81, +4, 89, FE=93 |
| 69 | 50, 66, +5, 61, FE=91 |
| 70 | 100, +3, +5, 120, +5, +4, 96 |
| 71 | 65, 101, +5, 79.5, FE=120 |
| 72 | 107, +2, +4, +5, 120, +5, +5, 109.5 |
| 73 | 97, +1, +5, 89, +5, 88.5 |
| 74 | 69, 51.5, +2, 106 |
| 75 | |
| 76 | 93, +4, +2, 65, +5, +5, 83, FE=101 |
| 77 | 83, +2, +5, +4, 89, +5, 60.5, FE=87 |
| 78 | 84, +3.5, +5, +3, 83, +5, +5, 70.5 |
| 79 | 115, +3, +4, +5, 105, +5, +5, 93 |
| 80 | 99, +1, 89, +5, +4, 89.5, FE=114 |
| 81 | 73, +2, +5, 84, +5, +5, 75 |
| 82 | 87, +2.5, +5, 92.5, 61, FE=96 |
| 83 | 58, +3, 71.5, +5, +5, 66, FE=90 |
| 84 | 87, +2, +5, 81, +4, +5, 105 |
| 85 | 101, 74.5, 71, FE=86 |
| 86 | 102, +5, +2, 112, +5, +5, 88.5 |
| 87 | 107.5, +2, 105, +5, 85, FE=103.5 |
| 88 | 101, +2.5, 95.5, +5, 80.5 |
| 89 | *65,+3, 62, 34, FE=87 |
| 90 | 46, +5, +2, 45 |