Yun Lu, Ph.D.Associate Professor - Organic ChemistryDepartment of Chemistry College of Arts and Sciences, Southern
Illinois University at Edwardsville, Edwardsville, Illinois
Office Phone: 618-650-3563 Fax: 618-650-3556 E-mail: yulu@siue.edu |
Education:
Ph.D., Organic Chemistry, 1996,
M.S., Organic Chemistry, 1991,
B.S.,
Chemistry, 1986,
Working
Experience:
Assistant
Professor,
Research
Assistant Professor, Utah State University, 2003-2004
Postdoctoral research fellow, Utah State University, 1998-2000, 2001-2003
Postdoctoral research fellow, Wayne State University, 2000-2001
Faculty,
Nankai University, 1996-1997;
Research
Interests:
My overall research centers on the mechanistic understandings of organic and biology-related reactions employing mechanistic analysis methodologies. Current research includes three projects, (i) structure-reactivity-mechanism relationship for hydride transfer reactions from alcohols to oragnic cations, (ii) biomimetic chemistry studies of the alcoholic oxidations by NAD+ coenzyme mediated by alcohol dehydrogenases, and (iii) enhanced reactivity of hydroxide ion in water containing cyclodextrin.
Teaching:
Organic chemistry 241a and 241b
The Organic chemistry of Enzyme Catalyzed Reactions 549
Graduate Seminar 575
Organic Lab 245 (coordinating)
General, Organic and Biol Chem Lab 124B (coordinating)
Nursing Chemistry Lab 124A (coordinating)
Publications:
41. 40. 39. 38. 37. 36. 35. (Above
publications were based on the work at Southern Illinois University
Edwardsville) 34. 33.
Kishan L. Handoo, Yun Lu, Vernon D. Parker “Resolution of
the Non-steady-state kinetics of the 2-step mechanism for the Diels-Alder
reaction between anthracene and tetracyanoethylene in Acetonitrile” J.
Am. Chem. Soc. 2003, 125, 9381. 32.
Yun Lu, Kishan L. Handoo, Vernon D. Parker
“Non-steady-state study of the SN2 reaction between
4-nitrophenoxide ion and methyl iodide in aprotiuc solvents containing water.
Evidence for a 2-step mechanism” Org. Biomol. Chem. 2003,
1, 36. 31.
Vernon
D. Parker, Yun Lu “Non-steady-state
kinetic study of the SN2 reaction between p-nitrophenoxide ion and
methyl iodide in acetonitrile” Org.
Biomol. Chem. 2003, 1,
2621. 30.
Yun Lu, Yixing Zhao, Kishan L. Handoo, Vernon D. Parker
“Hydride-exchange reactions between NADH and NAD+ model compounds
under non-steady-state conditions. Apparent and Real kinetic isotope effects” Org.
Biomol. Chem. 2003, 1,
173. 29.
Meng-Sheng Liao, Yun Lu, Vernon D. Parker, Steve Scheiner
“DFT calculations and spectral measurements of charge-transfer complexes
formed by aromatic amines and nitrogen heterocycles with tetracyanoethylene and
with chloranil” J. Phys.Chem. A 2003, 107, 8939. 28.
Kishan L. Handoo, Yun Lu, Yixing Zhao, Vernon D. Parker
“Resolution of the non-steady-state kinetics of the elimination of HBr from
2-(4-nitrophenyl)ethyl bromide in alcohol/alkoxide media)” Org.
Biomol. Chem. 2003,
1, 24. 27.
Meng-Sheng Liao, Yun Lu, Steve Scheiner “Performance of
Density-Functional Methods for Charge-Transfer Complexes” J. Comput. Chem.
2003, 24, 623. 26.
Martin
Newcomb, Runnan Shen, Yun Lu, Minor J. Conn, Paul F. Hollenberg, Daniel
A. Kopp, Stephen J. Lippard “Evaluation
of norcarane as a probe for radicals
in cytochrome P-450 and soluble Methane Monooxygenase- catalyzed hydroxylation
reactions” J Am. Chem. Soc. 2002, 124, 6879. 25.
Yun Lu, Yixing Zhao, Vernon D. Parker “Proton-transfer
reactions of methylarene radical cations with pyridine bases under
non-steady-state conditions. Real kinetic isotope effect evidence for extensive
tunneling” J Am. Chem. Soc. 2001,
123, 5900. 24.
Yixing Zhao, Yun Lu, Vernon D. Parker “Proton-transfer
reactions between nitroalkanes and hydroxide ion under non-steady-state
conditions. Apparent and real kinetic isotope effects” J
Am. Chem. Soc. 2001, 123, 1579. 23.
22.
Yixing Zhao, Yun Lu, Vernon D. Parker “Non-Steady-State
Kinetic Studies of the Real Kinetic Isotope Effects and Arrehenius Activation
Parameters for the Proton Transfer reactions of 9,10-Dimethylanthrance Radical
Cation with Pyridine Bases” J Chem Soc, Perkin Trans 2. 2001,
1481. 21. Jin-Pei
Cheng, Yun Lu, Xiaoqing Zhu,Shun Yongkai, Feng Bi, He, Jiaqi
“Hetereolytic and Homolytic N-H Bond Dissociation Energies of
4-Substituted Hantzch2,6-dimethyl-1,4-dihydro-pyridines and the Effect of
One-electron Transfer on the N-H Bond Activation” J.
Org. Chem. 2000, 65,
3853. 20.
Bingjun Zhao, Xiaoqing Zhu, Yun
Lu, Chizhong Xia, Jin-Pei Cheng “Kinetics and Mechanistic
investigation on the Oxidation of Hantzsch 1,4-Dihydropyridines with the
Tropylium Cation: A Model for NADH Oxidation.” Tetrahydron
Lett. 2000, 41, 257. 19.
Yun Lu,
Ming Xian, Xiaoqing Zhu, Kun Wang, Linjing Mu, Jin-Pei Cheng “Studies on
the Structure-Activity Relationship of NAD(P)H Models: Electronic Effects of
3-Acyls” J. Chem. Chinese Univ. 1999,
19, 59. 18.
Jin-Pei Cheng, Bo Liu, Yongyu Zhao,
Yongkai Sun, Xian-Man Zhang, Yun Lu, “Effects of Adjacent
Onium Cations and Remote Substituents on the H-A+ Bond Equilibrium
Acidities in Dimethyl Sulfoxide Solution. An Extensive Ylide Thermodynamic
Stability Scale and Implication for the Importance of Reasonance effect on Ylide
Stabilities.” J Org. Chem. 1999,
64, 604. 17.
Jin-Pei Cheng, Yun Lu,
Xiaoqing Zhu, LinJing Mu “Energetics of Multi-step vs.
One-step Hydride Transfer Reactions of Reduced Nicotinamide Adenine Dinucleotide
(NADH) Models with Organic Cations and p-Quinones”
J. Org. Chem. 1998, 63,
6108. 16.
Vernon D. Parker, Yixing Zhao, Yun
Lu, Gang Zheng “Application of Non-Steady-State Kinetics to Resolve
the Kinetics of Proton Transfer Reactions between Methylarene Radical Cations
and Pyridine Bases” J Am. Chem. Soc. 1998, 120,
12720. 15.
Jin-Pei Cheng, Kun Wang, Zheng Yin,
Xiaoqing Zhu, Yun Lu “NO Affinity. The Driving force of Nitric
Oxide (NO) Transfer in Biomimetic N-nitrosoacetanilide and N-nitrososulfoanilide
Systems” Tetrahedron Lett.
1998, 39, 7925. 14.
Jin-Pei Cheng, Yun Lu, Bo
Liu, Yongyu Zhao, Yongkai Sun, Difei Wang, Jianglin Mi “Effects of Double
Substitution of the Thermodynamic Stabilities of Nitrogen Radicals” Science
in China (series B)(Engl) 1998, 41,
215. 13.
Hongxing Wang, Jin-Pei Cheng, Wenxiang Gu, Gaojiu Zhang, Zhenwei Huan, Yun
Lu “Reactions of fluorocarbenes with carbonyl compounds - The
effects of para-substituents and pre-aromatic character on deoxygenation of aryl
aldehydes and tetraphenyl-cyclopentadienone” J.
Chem. Chinese Univ. 1998,
19(8), 723. 12.
Yun Lu, Duan Liu, Bingjun Zhao,
Xiaoqing Zhu, Jin-Pei Cheng “Bond Dissociation Energies of N(C)-H Bond
Cleavage of Substituted-1,4-dihydro-Hantzsch Pyridines and Corresponding Ion
Radicals: An Application on the Mechanistic Studies of Hantzsch Ester Mediated
Reductions” J. Chem. Chinese Univ. (suppl.)
1998,
19(8), 432. 11.
Jin-Pei Cheng, Yun Lu
“Kinetic, Thermodynamic and Mechanistic Studies on the Reduction of Carbenium
Ions by NAD(P)H Analogues” J. Phys. Org. Chem. 1997,
10, 577-584. 10.
Yun Lu, Bo Liu, Jin-Pei Cheng
“Studies on the Thermodynamics and Mechanism of the
Acid-Catalysed Reductions of N-arylfluoreneimines by NAD(P)H Models”